Circulating Anti-Phospholipase A2 Receptor Antibody Levels in Taiwanese Patients With Primary Membranous Nephropathy

Jin-Bor Chen ； Chien-Hsing Wu ； Shun-Chen Huang ； Yu-Jen Su ； Lung-Chih Li

《Acta Nephrologica》 32卷1期 (2018/03) Pp. 30-35

https://doi.org/10.6221/AN.201803_32(1).0005

摘要

BACKGROUND: The anti-phospholipase A2 receptor (anti-PLA2R) antibody has been reported to have good correlation with primary membranous nephropathy (pMN). This study investigated the anti-PLA2R antibody levels in Taiwanese patients diagnosed with this kidney disease. METHODS: Patients diagnosed with pMN by kidney biopsy were enrolled. The baseline circulating anti- PLA2R antibody levels in these patients were measured from 2013 to 2016. Meanwhile, laboratory parameters were also measured; namely, serum albumin, creatinine levels and daily proteinuria amount. These parameter levels were then compared with proteinuria unrelated to membranous nephropathy (MN) (non-MN group). RESULTS: The patients with pMN were grouped according to receipt of naïve treatment (naïve pMN group) or non-naïve treatment (non-naïve pMN group); the mean age in the two groups is 60.2 and 55.3 years, respectively. There were 7 males and 2 females in the naïve pMN group, and 12 males and 3 females in the non-naïve pMN group. The positive rate of the anti-PLA2R antibody in the naïve pMN group was 55.6% (5/9). The mean anti-PLA2R antibody levels were 143.24 RU/mL in the naïve pMN group and 59.53 RU/mL in the non-naïve pMN group. In the non-MN group, the mean anti-PLA2R antibody level was 1.92 RU/mL. The changes of anti-PLA2R antibody levels paralleled the proteinuria status in subjects with pMN. CONCLUSION: The positive rate of circulating anti-PLA2R antibodies is relatively low in Taiwanese patient with pMN. Nonetheless, the circulating levels of this antibody parallel the proteinuria status.

關鍵字

anti-PLA2R ； membranous nephropathy ； proteinuria