- 期刊
- OpenAccess
Gelsolin and Non-Alcoholic Fatty Liver Disease in Hemodialysis Patients
摘要
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has emerged as a global health problem. As NAFLD advances, the risks of developing more serious diseases such as cirrhosis, hepatocellular carcinoma, and cardiovascular diseases (CVD) also increase. In hemodialysis (HD) patients, NAFLD is more prevalent and is strongly associated with CVD. Plasma gelsolin (pGSN), a multi-functional protein, has been implicated in modulation of the immune system, inflammation, and metabolic syndrome. Its deficiency is correlated with HD mortality and vascular complications. The aim of this study was to investigate the association between pGSN levels and NAFLD in HD patients. METHODS: We measured pGSN levels and biochemical profiles in 110 stable HD patients, and characterized their fatty liver status with ultrasonography. RESULTS: Patients with NAFLD (n = 74) had higher body mass index, waist circumference and lower high-density lipoprotein, pGSN levels than the non-fatty liver group. Logistic regression analysis demonstrated pGSN to bethe independent factor associated with NAFLD (odd ratio, 1.21, 95% CI, 1.01-1.44, P = 0.036). pGSN is correlated with liver function tests, albumin, and vascular disease. CONCLUSION: The associations of pGSN and NAFLD in HD patients warrants further validation and investigation, and may pave new pathways for future research in chronic liver and kidney diseases.
延伸閱讀
- Lin, J. Y., Jeng, K. C., Haung, P. D., & Peng, K. P. (2018). Non-alcoholic Fatty Liver Disease: A Review for the Pathogenic Mechanism and Management. 童綜合醫學雜誌, 12(1), 6-19. https://www.airitilibrary.com/Article/Detail?DocID=20713592-201806-201806280011-201806280011-6-19
- Tai, C. M. (2015). Nonalcoholic Fatty Liver Disease in Severely Obese Patients [doctoral dissertation, Kaohsiung Medical University]. Airiti Library. https://doi.org/10.6832/KMU.2015.00067
- Ouaamari, A. E., & Minehira, K. (2013). Nonalcoholic Fatty Liver Disease: Its Mechanisms and Complications. International Journal of Endocrinology, 2013(), 927-928-212. https://doi.org/10.1155/2013/969748
- 劉乃瑄、許瀞分、陳正裕（2014）。The Assessment and Management of Non-Alcoholic Fatty Liver Disease。台灣家庭醫學雜誌，24(2)，62-76。https://doi.org/10.3966/168232812014062402002
- 劉俊人（2022）。Diagnosis and Epidemiology of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis。台灣醫學，26(3)，313-321。https://doi.org/10.6320/FJM.202205_26(3).0005