- 期刊
- OpenAccess
Association Between Physical Function Status and Mortality in Hemodialysis Patients: A Cohort Study
摘要
BACKGROUND: Currently, the morbidity and mortality rates in hemodialysis (HD) patients are high. Several risk factors are associated with survival in patients with HD. It is known that physical function status may correlate with overall survival in HD patients. This study uses Karnofsky Performance Status (KPS) to assess physical function status in patients in a HD room and its relationship with survival. METHODS: In this retrospective study, all-cause survival was recorded in a cohort of 574 HD patients, who were followed from November 2014 to November 2020. KPS was used to assess the physical function status at enrollment. The receiver operating characteristic (ROC) curve was used to evaluate the prediction value for mortality of KPS, KPS combined with hemoglobin, and KPS combined with hemoglobin plus albumin. RESULTS: Kaplan-Meier survival analysis revealed that the overall survival rates at five years between the better performance and the poor performance groups were 84.0% and 35.1%, respectively, with a log-rank test, X^2 = 32.450, P < 0.001. Multivariate Cox hazard regression analysis revealed that HD duration, higher KPS, hemoglobulin, and albumin were independent risk factors for the prognosis of survival time. The ROC analyses revealed that KPS combined with hemoglobin plus albumin seemed to better predict HD patient mortality than KPS alone and KPS combined with only hemoglobin. CONCLUSION: Higher baseline KPS, compared with lower baseline KPS, in HD patients is associated with better overall survival. KPS combined with nutrition index albumin and hemoglobin can have a better prediction on patient mortality than KPS alone.
延伸閱讀
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