- 期刊
- OpenAccess
The Association of Insulin Resistance with Calf and Waist Circumferences in Non-Diabetic Hemodialysis Patients
摘要
BACKGROUND: Insulin resistance (IR) has been associated with cardiovascular disease and protein-energy wasting in hemodialysis (HD) patients. The relationship between anthropometric measurement such as calf and waist circumferences and IR in non-diabetes patients is not well understood. The aim of this study was to test whether IR is correlated with body circumferences, body composition, and adipocytokines in this cohort of Taiwanese non-diabetic HD patients. METHODS: One hundred and eighteen non-diabetic patients receiving HD for more than 3 months were recruited for this cross-sectional study. Anthropometric and biochemical profiles were measured according to a standardized protocol. Body composition was assessed by whole-body bioimpedance spectroscopy using Body Composition Monitor (Fresenius Medical Care, Bad Homburg, Germany). Enzyme-linked immunosorbent assay kits were used to analyze the adiponectin and insulin. The IR index was assessed using homeostatic model assessment for insulin resistance (HOMA-IR), and HOMA-IR values ≥ 2.2 were considered IR. Patients were stratified by HOMA-IR values of ≥ 2.2 or < 2.2 and analyzed. RESULTS: Compared to non-diabetic HD patients without IR, non-diabetic HD patients with IR had higher calf and waist circumferences as well as higher serum leptin and fasting insulin levels, but lower levels of adiponectin. The HOMA-IR positively correlated with body mass index (r = 0.346, P < 0.001), calf circumference (r = 0.188, P = 0.041), waist circumference (r = 0.23, P = 0.012), adipose tissue mass (r = 0.251, P < 0.006), triglyceride (r = 0.322, P < 0.001), and leptin (r = 0.326, P < 0.001); while negatively correlated with adiponectin (r = -0.292, P = 0.001) and high-density lipoprotein cholesterol (r = -0.235, P = 0.01). There was a lack of correlation of HOMA-IR between vintage, relative overhydration, lean tissue mass, albumin, cholesterol, and C-reactive protein. CONCLUSIONS: In this cohort of non-diabetic HD patients, calf and waist circumferences are correlated with IR and adipocytokines.
延伸閱讀
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