開發真菌次級代謝物爲醫藥品

Development of Fungal Secondary Metabolites into Drugs

王聲遠(Sheng-Yuan Wang) ； 蕭明熙(Ming-Shi Shiao)

《Fungal Science》 16卷1&2期 (2001/06) Pp. 1-6

https://doi.org/10.7099/FS.200106.0001

摘要

面對廿一世紀人類疾病的新型態和後基因體世代，新藥開發己經進入了一個充滿機會與挑戰的新局面，未來新藥開發將依據功能基因體學與生物資訊學來掌握與人類重大疾病相關之基因做為新藥開發的標的，再藉快速篩檢技術去從微生物醱酵庫和化學品庫中快速找出一些活性化合物。之後，藉著結構生物學與分子模擬指引化學修飾，並引入組合化學技術去迅速地獲得先導化合物。配合建立轉殖動物去表達人類疾病相關基因，並呈現疾病特徵，即可成為藥物開發的病理動物模式。上述策略己經成為廿一世紀後基因體世代新藥開發的捷徑，國內若擬投入新藥開發，亦不能自外於此一大方向，但首先應建立一個微生物醱酵庫做為活性化合物的來源，並由建立一個真菌醱酵庫做為真菌次級代謝物來源開始。微生物醱酵庫並不等同於菌種中心。

關鍵字

功能基因體學 ； 生物資訊學 ； 次級代謝物 ； 新藥開發 ； 真菌 ； 酸酵庫

並列摘要

Recent advances in functional genomics and bioinformatics have provided many new targets to develop novel drugs for the treatment of human diseases. Applications of the new screening technology, such as high through-put screening and array technology, to the microbial fermentation library and chemical library provide a higher possibility to identify bioactive compounds. Furthermore, structure biology-based and molecular simulation-guided chemical modifications coupling with combinatorial chemistry comprise an efffective way to obtain lead compounds. Transgenic animals, which are produced to mimic human disease, become the animal models to evaluate the pharmacological potentials of lead drugs. For new drug discovery in the post-genomic era, the above-mentioned strategy should not be overlooked. To provide diversified secondary metabolites for the very demanding new lead screening, fermentation library should be established. It is most rewarded to start with a fungal fermentation library, which is not equivalent to a center of culture collection.

並列關鍵字

Functional genomics ； bioinformatics ； drug discovery ； fungi ； secondary metabolites ； fermentation library