Acute and Chronic Inflammation: Effect of the Risk Factor (s) on the Progression of the Early Inflammatory Response to the Oxidative and Nitrosative Stress

急性及慢性發炎：危險因子所引發的氧化與硝酸化壓力對發炎反應進展的影響

吳才元(James T. Wu) ； 劉衡生(Lily L. Wu)

《Journal of Biomedical & Laboratory Sciences》 19卷3期 (2007/09) Pp. 71-75

https://doi.org/10.30046/JBLS.200709.0001

摘要

許多的危險因子會引起發炎反應，危險因子會侵襲身體各部份的細胞，造成新的傷害及新的發炎疾病。細胞對於危險因子的最早反應爲急性發炎，當危險因子不再存在，急性發炎反應也會立即停止，而不會繼續導致氧化與硝酸化壓力或其他不良結果。如果危險因子繼續存在，急性發炎將發展爲慢性發炎。慢性發炎才是形成許多發炎疾病的主要原因。如果可以測量血液或尿液中急性與慢性發炎的指標，不僅可以獲知個體當時是否受危險因子的侵襲，而且可判斷其發炎的嚴重度。

關鍵字

急性發炎 ； 慢性系統性發炎 ； 危險因子 ； 氧化壓力 ； 指標

並列摘要

Multiple risk factors are known to exist that will attack cells at various parts of the body eliciting new inflammation sites hence new inflammatory diseases. Acute inflammation usually takes place first in response to the attack of the risk factor (s). As soon as the risk factor (s) is removed, the acute inflammatory response will stop. Conceivably, acute inflammation does not lead to oxidative and nitrosative stress or any serious adverse effect. However, when the risk factor (s) continues to exist, the acute inflammation will progress to chronic inflammation. It is the chronic inflammation that plays the major role in the pathogenesis of all inflammatory diseases. By monitoring soluble markers corresponding to the sequential events of both acute and chronic inflammation it is possible not only to determine whether an individual is currently exposed to risk factor (s) of inflammation but also the extent of overall inflammation reaction.

並列關鍵字

Acute inflammation ； chronic systemic inflammation ； risk factor ； oxidative stress ； biomarkers