血漿Visfatin濃度及基因多型性與第2型糖尿病有無合併大血管病變之關聯性研究

Increase of Visfatin Concentration and Gene Polymorphism Variants in Type 2 Diabetes Mellitus with Macrovascular Complications

吳凱娣(Kai-Di Wu) ； 林永政(Yung-Cheng Lin) ； 張道明(Dao-Ming Chang) ； 幸良蘭(Liang-Lan Hsing) ； 黃雅芳(Ya-Fang Huang)

《Journal of Biomedical & Laboratory Sciences》 21卷2期 (2009/06) Pp. 51-59

https://doi.org/10.30046/JBLS.200906.0003

摘要

本研究分析visfatin血漿濃度與基因多型性對於第2型糖尿病和糖尿病合併大血管併發症的影響。結果發現visfatin濃度增加，糖尿病合併大血管病變的危險性就愈高。在基因多型性的研究發現visfatin-948變異型異合子G/T基因型，表現在第2型糖尿病合併大血管病變組中明顯高於第2型糖尿病對照組。藉由觀察血漿visfatin濃度於第2型糖尿病對照組及合併大血管病變組中濃度的變化，可能有助於瞭解visfatin在大血管病變過程中所扮演的角色。

關鍵字

Visfatin ； 脂肪激素 ； 第2型糖尿病 ； 大血管病變

並列摘要

Objective: Visfatin, a newly discovered adipocytokine, has an insulin-mimetic effect that stimulates glucose to be metabolized and improve triglyceride to be accumulated and synthesized in preadipocytes. In this study, we explored the relationships between the plasma level of visfatin and genetic single nucleotide polymorphisms (SNPs) of visfatin gene in type 2 diabetes mellitus (T2DM) with and without macrovascular disease. Plasma visfatin was found to be elevated significantly in T2DM with macrovascular disease patients. Moreover, waist to hip ratio was independently associated with plasma visfatin level. There were statistically significant differences in visfatin -948 G→T genetic variants distribution between T2DM with macrovascular disease and the T2DM control group. The visfatin -948 G/T heterozygotes showed higher mean high-density lipoprotein cholesterol than the carriers of the G allele. The observation of changes in the plasma concentrations of visfatin seen in T2DM and T2DM with macrovascular diseases may exert beneficial effects in understanding roles of visfatin in physiologic activity and metabolic disorder.

並列關鍵字

visfatin ； adipocytokine ； type 2 diabetes mellitus ； macrovascular disease