Serum Adiponectin and Leptin Levels and Their Relations withInflammatory Factors and Metabolic Syndrome

血清脂聯素及瘦體素與發炎指標及代謝症候群的關係

孫玉珍(Yu-Chen Sun) ； 許隆安(Lung-An Hsu) ； 張璧月(Pi-Yueh Chang) ； 吳竹蘭(Tsu-Lan Wu) ； 詹爾昌(Err-Cheng Chan)

《Journal of Biomedical & Laboratory Sciences》 23卷4期 (2011/12) Pp. 140-146

https://doi.org/10.30046/JBLS.201112.0003

摘要

代謝症候群與脂肪組織衍生性的荷爾蒙有關，目前已知為糖尿病與心血管疾病的重要危險因子。本文測量577位健診民眾血清脂聯素與瘦體素含量與體內發炎因子含量的關係以及對代謝症候群的診斷能力。結果顯示血清瘦體素與腰圍，身體質量指數及血清E-selectin的含量最相關；血清脂聯素則與血清中HDL-C含量最相關。二者在診斷代謝症候群的能力上，無論男女脂聯素皆有較佳的敏感度與明確度。以邏輯迴歸分析顯示在校正年齡、腰圍及身體質量指數後，脂聯素每降低1mg／L，男性會增加1.32倍（95%信區間賴區間=1.13-1.54）的風險，女性會增加1.16倍（95%信賴區間=1.04－1.3）發生代謝症候群的風險。相反的，瘦體素對代謝症候群發生的風險性則無差別。總的而言，本研究發現血清脂聯素與瘦體素的含量與代謝症候群特徵及體內慢性發炎有關。然而，僅有血清脂聯素是不被年齡及肥胖影響的代謝症候群危險因子。

關鍵字

脂聯素 ； 瘦體素 ； 發炎指標 ； 代謝症候群

並列摘要

Background: Metabolic syndrome, associated with adipose-derived hormones, is known as an important risk for diabetes and cardiovascular disease. We measured serum adiponectin and leptin levels of 577 health-check patients and analyzed the relations with inflammatory factors and metabolic syndrome diagnosis. The results showed that serum leptin had high tightly correlations with waist circumference, body mass index and serum E-selectin; meanwhile, serum adiponectin had highest correlation with HDL-C level. For detecting the metabolic syndrome in both males and females, adiponectin had better sensitivity and specificity than leptin. After adjusting for age, waist and body mass index, the odds ratio (95% confidence interval) for metabolic syndrome corresponding to 1 mg/L decrease in adiponectin was 1.32 (1.13-1.54) in males and 1.16 (1.04-1.3) in females. In contrast, leptin showed no significant association with metabolic syndrome. In conclusion, serum adiponectin and leptin correlated with characteristics of metabolic syndrome and chronic inflammation. However, only adiponectin was risk factor for metabolic syndrome independent of age and obesity.

並列關鍵字

leptin ； adiponectin ； inflammatory markers ； metabolic syndrome