- 期刊
Procalcitonin在急診敗血症病患的診斷價值
Diagnostic Value of Procalcitonin for Sepsis Patients in the Emergency Department
摘要
Sepsis is the leading cause of mortality in critically ill patients. Therefore, accurate and timely diagnosis will limit morbidity, reduce costs, and improve patients' outcome. Procalcitonin (PCT) is known to be a reliable biomarker of bacterial infection. Therefore, the purpose of this study is to investigate the role of PCT in early diagnosis of bacterial infection and its correlation with high sensitivity C-reactive protein (CRP) and white blood cell (WBC) count in terms of disease severity for emergency department (ED) patients. For this purpose, 75 patients were evaluated (30 female, 45 female), 50 non-sepsis patients (29 male, 21 female) made up the control group from Sep 2010 to March 2011. PCT is a better bio-marker of bacterial infection compared with CRP and the WBC count. The best cut-off serum levels for PCT and CRP were 0.5 ng/ml and 50 mg/l. PCT level was more sensitive (82% versus 73%), a higher specific (96% versus 66%), and a higher Positive Predictive Value (96% versus 76%) than CRP level for differentiating bacterial from non-infective causes of inflammation. PCT levels, but not CRP levels, were significantly higher in sepsis and septic shock patients (p ＜ 0.01). PCT is a better marker of bacterial infection than CRP and WBC for emergency department patients and also a useful marker of the severity of infection.
並列摘要
Sepsis is the leading cause of mortality in critically ill patients. Therefore, accurate and timely diagnosis will limit morbidity, reduce costs, and improve patients' outcome. Procalcitonin (PCT) is known to be a reliable biomarker of bacterial infection. Therefore, the purpose of this study is to investigate the role of PCT in early diagnosis of bacterial infection and its correlation with high sensitivity C-reactive protein (CRP) and white blood cell (WBC) count in terms of disease severity for emergency department (ED) patients. For this purpose, 75 patients were evaluated (30 female, 45 female), 50 non-sepsis patients (29 male, 21 female) made up the control group from Sep 2010 to March 2011. PCT is a better bio-marker of bacterial infection compared with CRP and the WBC count. The best cut-off serum levels for PCT and CRP were 0.5 ng/ml and 50 mg/l. PCT level was more sensitive (82% versus 73%), a higher specific (96% versus 66%), and a higher Positive Predictive Value (96% versus 76%) than CRP level for differentiating bacterial from non-infective causes of inflammation. PCT levels, but not CRP levels, were significantly higher in sepsis and septic shock patients (p ＜ 0.01). PCT is a better marker of bacterial infection than CRP and WBC for emergency department patients and also a useful marker of the severity of infection.
延伸閱讀
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