- 期刊
C型肝炎核心抗原可作為C型肝炎病毒感染診斷指標
HCV Core Antigen Assay can be Used for Diagnosis of HCV Infection
摘要
本研究主要探討HCV cAg是否可作為HCV感染的診斷指標，檢測原理為化學冷光微粒免疫分析。實驗結果顯示HCV cAg試劑不同天精密度CV值為6.5%，可分析範圍5.82-19099.23 fmol/L；定量結果與HCV RNA濃度相關係數（r）達0.94，兩者間呈現高度正相關；定性結果之陽性預測值為98.2%，陰性預測值為98.8%。我們認為HCV cAg試劑性能優異而且為直接檢測病原，非常適合作為HCV感染的診斷指標。當進行大規模的社區篩檢時，可利用HCV cAg檢驗特性制定篩檢策略，將更快速而有效率地找出C型肝炎病毒帶原者。
並列摘要
The purpose of the study is to evaluate whether HCV cAg assay can be used as a marker of HCV infection. The principle of detection is chemiluminescent microparticle immunoassay. The between-day precision of this assay is 6.5% , the analytical measurement range is from 5.82 to 19099.23 fmol/L, the correlation coefficient (r) was determined as 0.94 between HCV cAg and HCV RNA level. The positive predictive value and negative predictive value were 98.2 and 98.8%, respectively. HCV cAg reagent has excellent performance as a direct test for HCV, which is very suitable as a diagnostic marker of HCV infection. In large-scale community screening, we should use the feature of HCV cAg assay to develop a strategy which will identify HCV carriers more quickly and efficiently.
延伸閱讀
- 柳逸照（1993）。B型肝炎表面抗原與B型肝炎表面抗體檢驗試劑之評估。藥物食品檢驗局調查研究年報，()，216-225。https://doi.org/10.6946/ASRNL.199309.0216
- 涂佳宏（2008）。C型肝炎血清標記檢查。健康世界，(276)，52-53。https://doi.org/10.6454/HW.200812.0052
- 杜慧珍、傳淑卿、紀長文、柳逸照、賴秀芸、楊若英、陳作琳、林嘉伯（2006）。C型肝炎抗體對照血清組之製備。藥物食品檢驗局調查研究年報，()，110-120。https://doi.org/10.6946/ASRNL.200612.0110
- 吳啟榮、黃怡翔（2020）。Guidelines and Benefits for the Treatment of Chronic HCV Infection。內科學誌，31(3)，150-156。https://doi.org/10.6314/JIMT.202006_31(3).03
- Cavoli, G. L., Zagarrigo, C., Schillaci, O., Servillo, F., Tralongo, A., Coglitore, M., Spadaro, F., Scimeca, C., Destri, N. L., & Rotolo, U. (2012). Hepatitis C Virus Core Antigen Test in Monitoring of Dialysis Patients. Hepatitis Research and Treatment, 2012(), 75-78. https://doi.org/10.1155/2012/832021