The Life Skills Inventory for individuals with physical disabilities was examined as a life skill measure for people with schizophrenia. We have recruited 92 individuals with schizophrenia who had no obvious general cognitive barriers from a community rehabilitation center in Southern Taiwan to participate in the study. All participants have completed the Life Skills Inventory and were rated by the center’s occupational therapists using the Life Skills Inventory at the same time. Results from this study show that the Life Skills Inventory in individuals with schizophrenia had great differences between clients’ self-report and occupational therapists’ ratings. The patients’ self-report scores were significantly higher than the therapists’ ratings in the total and subscales’ scores. The discrepancy challenges the accuracy and utility of the Life Skills Inventory for individuals with schizophrenia. It is concluded that when assessing life skills of people with schizophrenia, it is important not to use only one dimensional measure (whether self- report or professional assessment), but to combine subjective and objective measures in order to fully understand the complete picture of clients’ life skills.