A 61-year-old housewife was suffering from a right upper-quadrant abdominal pain for one month. An abdominal computed tomography scan revealed a gas-containing irregular hypodense mass in the right lobe of liver and ultrasound examination showed a large hypoechoic gas-containing mass in the same area. A liver abscess was confirmed by needle aspiration with pus. Barium enema study revealed extravasation of barium into the liver parenchyma from the hepatic flexure of the colon. Surgical intervention revealed an indurative tumor extending from the hepatic flexure of the colon into the liver and a perforation hole connecting the colon lumen to the abscess cavity. The histopathology confirmed the diagnosis of malignant fibrous histiocytoma of the colon with direct invasion to the liver. The patient died of septic shock three months later due to anastomotic leakage.