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Fatal Pancreatitis Secondary to Iatrogenic Intramural Duodenal Hematoma: Report of a Case

醫源性十二指腸壁內血腫合併致命性胰臟炎:一病例報告

摘要


十二指腸壁內血腫合併致命性胰臟炎是相當罕見的。我們在此報告一個因十二指腸潰瘍出血接受上消化道內視鏡治療,而引發壁內血腫與嚴重胰臟炎的病例。此病患於接受緊急內視鏡檢查時在局部出血位置注射腎上腺素(1:10000)止血。之後在注射部位形成一個巨大的壁內血腫,並造成所覆蓋的十二指腸漿膜撕裂與大量的腹膜內出血。病患因出血不止而需接受局部腸切除手術。此十二指腸壁內血腫同時造成壞死性胰臟炎合併細茵感染,病患於四週後因敗血症而死亡。我們同時回顧相關文獻中其他七位醫源性十二指腸壁內血腫的病例,並討論其臨床表現與預後。

並列摘要


Fatal pancreatitis secondary to intramural duodenal hematoma is very rare. We report a case with such condition in which the duodenal hematoma was induced by upper gastrointestinal endoscopic injection therapy. The patient received emergent endoscopy for active bleeding of duodenal ulcers. After a 30mL local injection of epinephrine (1:10000) to stop the bleeding, a huge intramural hematoma formed and was complicated with laceration of the duodenal serosa and massive intraperitoneal bleeding. Therefore, a surgical bowel resection became necessary to stop the bleeding. The duodenal hematoma also caused acute pancreatitis with infected necrosis. The patient died of sepsis four weeks later. We also review 7 other cases of iatrogenic intramural duodenal hematoma reported in the English literature and discuss the clinical presentations and outcomes.

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