Fatal pancreatitis secondary to intramural duodenal hematoma is very rare. We report a case with such condition in which the duodenal hematoma was induced by upper gastrointestinal endoscopic injection therapy. The patient received emergent endoscopy for active bleeding of duodenal ulcers. After a 30mL local injection of epinephrine (1:10000) to stop the bleeding, a huge intramural hematoma formed and was complicated with laceration of the duodenal serosa and massive intraperitoneal bleeding. Therefore, a surgical bowel resection became necessary to stop the bleeding. The duodenal hematoma also caused acute pancreatitis with infected necrosis. The patient died of sepsis four weeks later. We also review 7 other cases of iatrogenic intramural duodenal hematoma reported in the English literature and discuss the clinical presentations and outcomes.