Webs in the common bile duct (CBD) are rare. This report describes a case of CBD web in association with gallstones and a large CBD stone (50 mm×26 mm) in a 51-year-old female. The diagnosis was made on endoscopic retrograde cholangiopancreatography (ERCP) and the web was dilated by controlled radial expansion balloon. Self-limited bleeding occurred after web dilatation. The large and difficult CBD stone was managed by periodical endoscopic biliary stenting, and two extraction attempts failed. The patient underwent uneventful open cholecystectomy and choledocholithotomy. This report reviews relevant cases reported in English; diagnostic and therapeutic aspects are discussed.