A fish bone lodged in the hypopharynx or esophagus is a medical emergency, which requires prompt treatment. However, it becomes a great challenge to both otolaryngologists and gastroenterologists when it happens in patients with difficulties in opening their mouths. Herein, we reported a 73-year-old woman with trismus who had a fish bone impacted at the tongue base. The limited mouth opening made insertion of instruments through oral cavity and removal of the foreign body challenging. The medical plight was resolved by using a transnasal esophagogastroduodenoscope and the fish bone was retrieved by a biopsy forceps through nasal cavity successfully.