- 期刊
BMI-1 Expression in Hepatocellular Carcinoma and Its Clinicopathological Significance: Preliminary Report
BMI-1在肝細胞癌的表現與其臨床病理之重要性：初報
摘要
Background and Aim: The oncogene BMI-1 is an inhibitory regulator of the INK4a/ARF locus including two tumor suppressor genes, p16INK4a and p14ARF. We investigate the clinicopathological significances of BMI-1 in hepatocellular carcinoma (HCC) and analyze the association between BMI-1 expression and p16INK4a and p14ARF. Methods: We examined the expression of BMI-1, p16INK4a and p14ARF in 20 surgical specimens of HCC by performing immunohistochemical analysis. Results: Positive BMI-1 staining was shown in 11 (55%) patients. Nine of the 11 patients with positive and 5 of the 9 patients with negative BMI-1 staining demonstrated negative p16INK4a staining, respectively, and the ratio was not significantly different between the two groups (p=0.336). For p14ARF staining, all 20 HCC patients showed diffusely positive staining with variable staining intensities. In addition, BMI-1 expression showed no correlation with age, sex, the proportion of patients with liver cirrhosis, tumor size or number, the degree of tumor differentiation, or the proportion of α-fetoprotein (AFP) abnormality. However, positive BMI-1 expression tended to be associated with a concentration of AFP and the proportion of patients with AFP higher than 400 ng/mL (p＜0.1). Conclusion: The expression of the BMI-1 oncogene had no relation to the tumor suppressor gene p16INK4a or p14ARF, patients' age, sex, liver cirrhosis, tumor size, tumor number, and tumor differentiation in HCC. The expression of BMI-1 trended to be associated with the AFP level.
並列摘要
Background and Aim: The oncogene BMI-1 is an inhibitory regulator of the INK4a/ARF locus including two tumor suppressor genes, p16INK4a and p14ARF. We investigate the clinicopathological significances of BMI-1 in hepatocellular carcinoma (HCC) and analyze the association between BMI-1 expression and p16INK4a and p14ARF. Methods: We examined the expression of BMI-1, p16INK4a and p14ARF in 20 surgical specimens of HCC by performing immunohistochemical analysis. Results: Positive BMI-1 staining was shown in 11 (55%) patients. Nine of the 11 patients with positive and 5 of the 9 patients with negative BMI-1 staining demonstrated negative p16INK4a staining, respectively, and the ratio was not significantly different between the two groups (p=0.336). For p14ARF staining, all 20 HCC patients showed diffusely positive staining with variable staining intensities. In addition, BMI-1 expression showed no correlation with age, sex, the proportion of patients with liver cirrhosis, tumor size or number, the degree of tumor differentiation, or the proportion of α-fetoprotein (AFP) abnormality. However, positive BMI-1 expression tended to be associated with a concentration of AFP and the proportion of patients with AFP higher than 400 ng/mL (p＜0.1). Conclusion: The expression of the BMI-1 oncogene had no relation to the tumor suppressor gene p16INK4a or p14ARF, patients' age, sex, liver cirrhosis, tumor size, tumor number, and tumor differentiation in HCC. The expression of BMI-1 trended to be associated with the AFP level.
延伸閱讀
- Chang, W. Y., & Lin, Z. Y. (1990). 血中B蛋白與肝癌及肝硬化關係之研究. The Kaohsiung Journal of Medical Sciences, 6(11), 599-605. https://doi.org/10.6452/KJMS.199011.0599
- Lu, S. C. (2014). 微型核醣核酸-122和B型肝炎病毒量與肝細胞癌發展的相關性：巢式病例對照研究 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2014.01501
- 何樹仁、霍德義（2018）。非侵入性肝功能指標在評估肝癌預後所扮演的角色。臨床醫學月刊，82(4)，601-604。https://doi.org/10.6666/ClinMed.201810_82(4).0110
- Wu, C. F. (2006). B型肝炎病毒量的長期變化趨勢和肝細胞癌的危險性:病例世代研究 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2006.00656
- Liu, C. C. (2009). 肝硬化相關細胞激素對B型肝炎誘導肝細胞癌之預測：蛋白質微陣列分析 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2009.01091