Current Status of Alcoholic Liver Disease in Taiwan

台灣的酒精性肝病現況

胡瑞庭(Jui-Ting Hu) ； 楊素卿(Suh-Chin Yang) ； 黃秀芬(Shiu-Feng Huang) ； 林志陵(Chih-Lin Lin) ； 林帛賢(Po-Hsien Lin) ； 曾錙翎(Tzu-Ling Tseng) ； 楊賢馨(Sien-Sing Yang)

《臺灣消化醫學雜誌》 28卷2期 (2011/06) Pp. 234-241

https://doi.org/10.6557/GJT.201106_28(2).0007

摘要

臺灣因經濟的繁榮、酒的消耗量增加及飲酒行爲改變，導致酒精性肝病住院治療病例的增加。酒精性肝病根據組織學變化被分類，包括酒精性脂肪肝、酒精性肝炎、酒精性肝硬化、及合併酒精性肝炎及肝硬化。自由基和脂肪過氧化造成肝細胞損傷和形成Mallory體。酒精引起的低氧症、脂肪過氧化和乙醛可以激活星形細胞產生纖維化，本文討論酒精性肝病的臨床特點和治療，酒精肝炎的病人應憑估嚴重程度，及早使用類固醇療法改善存活率。

關鍵字

酒精 ； 肝病 ； 肝炎 ； 肝硬化

並列摘要

Economic prosperity in Taiwan has lead to increased ethanol consumption resulting in increasing cases of hospitalization for alcoholic liver disease. Alcoholic liver disease based on histological findings is classified into four categories: alcoholic fatty liver, alcoholic hepatitis, alcoholic cirrhosis and alcoholic hepatitis superimposed on cirrhosis. Damages caused by free radicals and lipid peroxidation have lead to the ballooning change of hepatocytes and the formation of Mallory bodies. Ethanol-induced hypoxia, lipid peroxidation, and acetaldehyde activate the stellate cells and thus increase matrix production and fibrogenesis. In this review, various clinical features and treatments of alcoholic liver disease are discussed. It is recommended that patients with alcoholic hepatitis be assessed with appropriate quantitative scores for early steroids therapy to improve survival.

並列關鍵字

alcohol ； liver disease ； hepatitis ； liver cirrhosis