Linear static, nonlinear static, and nonlinear dynamic analyses are conducted to estimate the progressive collapse resistance of a RC building under four threat-independent, column-removed conditions. A step-bystep procedure recommended by the U.S. General Service Administration (GSA) is used for the linear static analysis. Load-displacement response curves obtained from the three methods are compared to investigate the force-based dynamic amplification factor (DAF). It is observed that a constant DAF of 2.0 is conservative for estimating the collapse resistance of a ductile column-removed building. However, the linear static procedure may fail to appropriately simulate the inelastic response of the building. A capacity curve, which is constructed from the nonlinear static load-displacement response, may be applied to approximate prediction of the collapse resistance and the DAF for a column-removed building. An analytical methodology is proposed and used to demonstrate the dependence of the force-based DAF on hinge model parameters. It is shown that the analytical method is capable of predicting the collapse resistance and the force-based DAF of an inelastic structure under vertical downward loadings.