The 2016 Meinong earthquake caused serious damages in Tainan, especially to several mid to high-rise mixed-use residential and commercial buildings. Earthquake reconnaissance investigations show the major causes of damaged structure as follows: (1) soften and weakly first story and (2) non-ductile detailing of structure member. In order to grasp the seismic performance of the mid to high-rise buildings, a series of specimens were designed with the structural characteristics of the typical mixed-use residential and commercial buildings in Taiwan in the 1990s. A 1/2 scale three-story reinforced concrete (RC) frame infilled with RC walls has been subjected to near fault and far field earthquakes on the novel shaking table. The scaled specimen will be extended to seven-story by applying the concept of modular design, which is going to be tested in the series study. The dynamic behavior and damage features of the building under near-fault ground motions will be studied. In this paper, the design of the specimen, instrumentation layout, and the findings from the shaking table test from the near-fault ground motion will be introduced and discussed. Moreover, the test results were compared with the analysis results using the nonlinear dynamic analysis method. The comparison provides an important reference for researches on developing the seismic performance assessment tools for mid to high-rise RC buildings.