Over the past decade, the use of Video-assisted thoracic surgery (VATS) has become widespread and has allowed surgeons to perform complex procedures that avoid long thoracotomy. However, despite demonstration of its technical feasibility, the application of VATS for lung cancer has remained infrequent. With the development of new instruments and surgeons gaining more experiences, VATS in the management of lung cancer is now being used from diagnosis to treatment, especially VATS major lung resection has been shown to be a safe operation in experienced hands. When compared with traditional open thoracotomy, VATS has reduced the degree of post-operative chest wall trauma, pain and less pulmonary function disturbance. Intermediate to long-term survival for lung cancer patients who underwent VATS resection appears similar to open surgery. We anticipated that, in near future, with the continue advancements in new technologies, VATS will become more mature and will significantly play an important role in patients with lung cancer.