The development of department-based curriculum can help technology institutes to raise the professional human resource that has highly practicality for the enterprise. The purpose of technological education is to raise practical human resource for the country. Therefore the curriculum planning of the technological schools should be based on the idea of department-based curriculum. When students graduate from the technological schools they will have the basic capability of job; that will be achieved the idea vision of school education. This research tries to understand the whole situation and solving methods in establishing the department-based curriculum. In the beginning curriculum-committee of the department should coincide the concept of department-based curriculum planning, and then all teachers try to establish department-based curriculum of the chemical engineering and biotechnology department. On the support of school administrative system and all of the teachers involve in the curriculum planning and finally establish the department-based curriculum.