This article discusses some of the ways in which sound acts both as a medium of revelation about the self, the world and the "Totally Other," and as a unique human means for answering to or establishing relations with different levels of otherness. The immateriality and yet perceivable presence of sound, as well as the fundamental anthropological dimensions of hearing and listening have been employed by different cultures as powerful metaphors for interpreting reality and the spiritual world. Although technological progress appears to have trivialised the nature of sound and altered human attitudes towards it, sound retains its elusiveness and the power to define the place of humanity in the midst of reality. Hence, sound provides an exclusive perspective for understanding the human nature, while concern about sound is a form of solicitude for the human life.