In the late Qing Dynasty, the dissemination of Catholicism in Guangxi Zhuang ethnic region was led by the Paris Missionaries Society, which expended from marginal poor villages to central towns along the east, south, and west routes. The missionaries adopted the indirect missionary strategy of localization and relied on such charity affairs as medical care, education, and relief to spread religious doctrines and to develop believers. However, due to the comprehensive effects of cultural tradition conflicts, psychosocial restraints, and weak faith foundation, the dissemination effect of Catholicism in Guangxi Zhuang ethnic region in the late Qing Dynasty was not obvious.