- 期刊
Synthesis, Anti-anergic and Anti-inflammatory Activities of N-substituted Benzyl-6 (or 7)-chloro-2,3,4,9-tetrahyd rofuro [2,3-b] quinolin-3,4-diones
並列摘要
A series of N-su bstituted benzyl-6 (or 7)-chloro-2,3,4,9-tetrahydrofuro[2,3-b]qu inolin-3,4diiones (l3a-o, 16a-o) were synthesized, and evaluated for anti-allergic and anti-inflammatory activities by inhibition of mast cell degranulation, neutrophil degranulation, and superoxide formation in neutrophils. In general, 7-chloro-substituted derivatives (13a-o) showed more inhibitory activity during fMLP-induced neutrophil degranulation and compound (131) exhibited the highest activity at 30 uM; on the other hand, 6-chloro-substituted derivatives (16a-o) showed stronger inhibition during fMLP-induced superoxide formation in neutrophils and compound (16f) displayed the greatest effect at 30 uM
延伸閱讀
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