- 期刊
Studies on Quinazolines. 12.^1 Design of 4-Amino-8-arylquinazoline Derivatives as Potential Non-Peptide Corticotropin-Releasing Hormone Receptor I (CRHR1) Antagonists
並列摘要
Four 8-aryl-4-(N-cyclopropylmethyl-N-propyl)amino-2-methylquinazolines were synthesized, and their binding affinity for corticotropin-releasing hormone type 1 receptor (CRHR1) was investigated. Compounds 22 and 23 possessed high rCRHR1 affinities of K(subscript i)=13 and 50 nM, respectively. The quinazoline derivatives showed parallel SAR to the other known bicyclic system; the ortho-substituent on the 8-aryl ring is indispensable.
延伸閱讀
- 蔡秉均（2012）。Study on the Diels-Alder reactions of Masked 4-Substituted-o-benzoquinones and (1S)-7,7-dimethyl-1-(nitrosocarbonyl)bicyclo[2.2.1]heptan-2-one〔碩士論文，中原大學〕。華藝線上圖書館。https://doi.org/10.6840/cycu201200059
- 徐瑞靜（2008）。(1)Synthesis of modified lithocholic acids: coumarin, nitro-2,1,3-benzoxadiazole and other functional groups as effective anticancer agents and biological probes.(2)Analogues of Malyngamide 1 and Isomalyngamide A as inhibitors of sialyltransferases: A structure activity relationship study of chain-length and functional dependence.〔碩士論文，國立中央大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0031-0207200917355211
- 曹福寶（1977）。Studies on Substituted 8-Quinolinols as Metal Extractants III. Extraction of Cd(II), Hg(II), Mn(II), and Zn(II) with 2-(p-Chlorostyryl)-8-quinolinol。化學，(66年1)，12-14。https://doi.org/10.6623/chem.1977003
- 鍾騰輝（2018）。1. Synthesis of Naphthoquinone Derivatives in aqueous medium 2. Synthesis of (Z)-6H-benzo[7,8]thiocino[4,3-b]quinoline Derivatives From Morita–Baylis–Hillman adducts〔碩士論文，國立臺灣師範大學〕。華藝線上圖書館。https://doi.org/10.6345/THE.NTNU.DC.050.2018.B05
- 王文揚（2014）。I.Aliphatic Hydroxamates Capped with Substituted Aryl Indole as Histone Deacetylase InhibitorsII.Structure Optimization for Ortho-Aryl N-Hydroxycinnamides as HDAC 8 Isoform-Selective Inhibitors against Cancer CellsII.Structure Optimization forOrtho-Aryl N-Hydroxycinnamides as〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-3107201413142600