巨大乳促素瘤－病例報告

Macroprolactinoma – Report of a Case

陳信典(Hsin-Dean Chen) ； 張幼國(You-Kuo Chang) ； 鄭王武(Wang-Wu Cheng)

《慈濟醫學雜誌》 4卷1期 (1992/03) Pp. 51-56

https://doi.org/10.6440/TZUCMJ.199203.0051

摘要

乳促素瘤為一常見的腦垂腺腫瘤。它分泌過多的乳促素而造成臨床上常見的閉經，乳溢及不孕。由於bromocriptine的發明使得治療方法有很大的進步。本病例報告一位25歲女性病人因閉經－乳溢症候群而住院。電腦斷層顯示一巨大腺瘤並有蝶鞍外侵犯。免疫組織化學染色證實為一分泌乳促素的腺瘤。經外科手術及放射治療，仍殘留腫塊及乳促素大於200ng/ml，病人後來接受bromocriptin治療，殘留腫塊呈囊狀變化，血中乳促素濃度恢復正常。

關鍵字

閉經－乳溢症候群 ； 高乳促素血症 ； 巨大乳促素瘤

並列摘要

Prolactinomas that secrete prolactin are the most common type of pituitary tumor. Hyperprolactinemia is a problem in clinical endocrine practice. It causes amenorrhea, galactorrhea, and infertility. Most of the recent therapeutic advances have stemmed from the advent of bromocriptine therapy.
A 25-year-old woman was hospitalized due to amenorrhea-galactorrhea syndrome. Brain computerized tomography disclosed a macroadenoma with suprasellar expansion. However transhpenoidal microsurgery and radiation therapy were done, there was a residual mass and prolactin level remained elevated to more than 200ng/ml. Bromocriptine therapy was started and resulted in the cystic change of the residual tumor and the prolactin level became normal over 8 months.

並列關鍵字

amenorrhea-galactorrhea syndrome ； hyperprolactinemia ； macroprolactinoma