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Alzheimer病並存澱粉樣腦血管病附10例臨床及病理分析

Alzheimer's Disease Accompanied by Cerebral Amyloid Angiopathy (A Clinicopathological Analysis of 10 Cases)

摘要


245例連續腦屍解病例中篩選出10例Alzheimer病並存的澱粉樣腦血管(CAA)病例,臨床病程0.5~6年,表現不同程度智能障礙,屍解見不同程度的腦萎縮。CAA病變廣泛累及腦葉皮層和腦膜血管,老年斑(SP)多見於腦葉皮層,而神經原纖維纏結(NFT)則多見於海馬。臨床表現痴呆嚴重的病例,腦內CAA、SP和NFT病變亦嚴重。

並列摘要


In a series of 245 autopsy cases, we selected 10 pathologically verified cases of Alzheimer’s disease with cerebral amyloid angiopathy (CAA). Clinical courses vary from 0.5 to 6 years. These patients present some extent of mental retardation. At autopsy, some degree of brain atrophy are found. CAA can invade throughout cortex and leptomeninges vessels. Senile plaques (SP) often appear in the cortex, but neurofiblillary tangles (NFT) are usually observed in hippocampus. The more severe dementia, the more severe pathologic changes such as CAA, SP and NFT.

並列關鍵字

senile plaque neurofibrillary tangles NFT

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