An Epidemiological Study of Lip and Palate Cleft in Taiwan: Prevalence Trend and Familial Clustering

台灣地區唇顎裂之流行病學研究─盛行率趨勢及家族聚集現象

蕭正光(Cheng-Kuang Shaw) ； 陳建仁(Chien-Jen Chen) ； 李明亮(Ming-Liang Lee)

《慈濟醫學雜誌》 7卷2期 (1995/06) Pp. 89-95

https://doi.org/10.6440/TZUCMJ.199506.0089

摘要

本研究的目的是估計台灣地區唇顎裂之出生盛行率，以及其家族聚集情形。本研究分析1980至1982年，衛生署保健處所報告的130,821位新生兒，以及1990至1992年，87,747位新生兒，發現這13年期間唇顎裂並無明顯的變化趨勢。唇裂合併／不合併顎裂之出生盛行率為每千人1.12，單純顎裂為每千人0.66。約15%之唇顎裂新生兒之出生體重低於2500g，比台灣地區低體重新生兒之平圾盛行率高出2倍。本研究亦訪視136位唇裂合併／不合併顎裂患者，其中有18位親屬(9.55%)亦為病例，這18位病例親屬有17位和指標病例罹患同型之唇顎裂，僅一位罹患單純顎裂，一等親親屬較一般族群危險性高10倍以上，而二等親及三等親親屬則比一般族群危險性高2至3倍。

關鍵字

唇顎裂 ； 盛行率趨勢 ； 家族聚集

並列摘要

This study was carried out to estimate the birth prevalence of lip and palate cleft in Taiwan and to explore its familial clustering. In a survey of 130,821 births during 1980 to 1982 and 87,747 births during 1990 to 1992, the birth prevalence of cleft lip with or without cleft palate (CL/P) and isolated cleft palate (CP)show no significant change during the 13 years period. The birth prevalence of CL/P and of CP was found to be 1.12 and 0.47 per 1,000, respectively. The sex ratio (male to female) varied between the different types of clefts: CL/P had a sex ratio of 1.38 and CP had a ratio of 0.66. The prevalence of birthweight under 2500G for cleft infants was 15.3% which was more than twice higher than the average prevalence of low birthweight in Taiwan. Although only 9.55% of 136 intereviewed CL/P index cases had a family history of cleft, the frequency of clefts in the relatives was in excess of that for the general population. Among the 18 affected relatives of CL/p index cases, only one was affected with isolated cleft palate and the others with CL/P.

並列關鍵字

Lip and palate cleft ； prevalence trend ； familial clustering