Vitamin D Receptor Alleles and Bone Mineral Density of Chinese in Taiwan

中國人維生素D受體對偶基因和骨質密度之關係

蕭正光(Cheng-Kuang Shaw) ； 陳嘉祥(Chia-Hsiang Chen) ； 曾凱元(Kai-Yuan Tzen)

《慈濟醫學雜誌》 10卷2期 (1998/06) Pp. 81-86

https://doi.org/10.6440/TZUCMJ.199806.0081

摘要

本研究之目的在於探討維生素D受器基因(VDRG)之RFLP多形性是否可以預測中國人之骨質密度(BMD)及骨質密衰退率。89位(63位女性，26為男性，平均年齡57.5歲)居住於林口鄉之志願者參加本研究，於1990年及1995/96年以雙光子吸收儀測期腰椎骨質密度，平均追蹤期為5.8年。以BsmI限制酶切害VDRG，其中呈現限制酶切點為b，不呈現限制酶切點為B。共有7位(8%)為BB，11位(12%)為Bb及71位(80%)為bb。在中國女性，雖基因型為BB者其BMD低於Bb及bb者(0.813g/cm2 vs. 1.029g/cm2)，但在調整體格指數、年齡及停經三因素後，其差異並未達統計顯著水準。在中國男性，BB基因型之BMD亦略低於其他基因型(1.066g/cm2 vs. 1.248g/cm2)，但在調整體格指數及年齡二因素後，其差異亦未達統計顯著水準。骨質衰退率在不同基因型並無顯著之差異。(慈濟醫學1998;10:81-86)

關鍵字

維生素D受體 ； 骨質密度 ； 骨質密度變化率

並列摘要

This study was conducted to determine whether a restriction fragment length polymorphism in the vitamin D receptor gene (VDRG) predicts lumbar spine bone mineral density (BMDls)and the annual bone density change rate in Chinese. Eighty-nine healthy volunteers (63 women and 26 men, mean age57.5 yaers)living in Lin-Kou Township were recruited. The BMD of the lumbar spine of each subject was measured by dual-photon absorptiomerty in 1990 and then the measurement was repeated in 1995/96, with an average follow-up period of 5.8years. The genotype was based on the presence (b) or absence (B) of a BsmI restriction enzyme site in the VDRG. There were 6(6.7%) BB homozygotes, 11 (12.3%) Bb heterozygoted and72(81.0%) bb homozygotes. Although the BMDls value for postmenopausal women with BB genotype was significantly lower than that for postmenopausal women with bb genotype (0.813 g/cm2), a comparison of BMDls adjusted for body mass index, age, and menopause status among genotypes showed no significant difference. In addition, there was no significant difference for annual bone density change rate among the three genotypes in postmenopausal women. The BMDls value for men with BB genotype was lower than that for men with bb genotype (1.066g/cm2 vs. 1.248g/cm2). However, after adjustment for body mass index and age, no significant difference was shown. The results show thast the polymorphisms of the BsmI restriction site in the VDRG are not predictive of the bone density change rate nor BMDls in a sasmple of healthy Chinese volunteers in Taiwan.(Tzu Chi Med J1998;10:81-86)

並列關鍵字

Vitamin D receptor ； bone mineral density ； BMD change rate