- 期刊
Drug Resistance of Mycobacterium tuberculosis in Eastern Taiwan
台灣東部地區結核菌抗藥性現況
摘要
目的：評估台灣東部地區當核菌的抗藥性現況。材料與方法：西元2001年1月到2002年12月間在慈濟醫院培養出的結核桿菌菌株有252例使用比例法完成藥物感受性試驗。結果：72株(28.6%)有抗藥性問題，各個藥物的綜合性抗藥比例分別為isoinazid, 21.8%；streptomycin, 8.3%，rifampin, 12.7%和ethambutol,12.7%。190例未治療過病人的菌株中16.8%有抗藥性。原發性抗藥比例分別為isoinazid, 11.0%；ethambutol, 5.8%；streptomycin, 5.3%和rifampin, 2.1%。原發多重抗藥比例為2.1%。62例曾治療過患者的菌株中64.5%有抗藥性。獲得性抗藥比例分別為isoinazid, 54.8%；streptomycin, 17.7%；rifampin, 45.2%和ethambutol, 33.9%。結論：台灣東部地區的抗藥性比例非常地高，應當定期地在東部監測抗藥性的變化。應採取適當措施例如直接監督治療來保護rifampin以減少多重藥物抗藥性。
並列摘要
Objective：To evaluate patterns of drug resistance of Mycobacterium tuberculosis in Taiwan. Materials and Methods：Two hundred and fifty-two isolates collected from January 2001 through December 2002 were tested for drug susceptibility using the agar propotion method at Tzu Chi General Hospital. Results: The overall rate of resistance to at least one drug was 28.6%. The overall resistance rates to individual drugs were 21.8% to isoniazid, 8.3% to streptomycin, 12.7% to rifampin, and 12.7% to ethambutol. Among the 190 isolates from patients without prior treatment, 16.8% of the strains were resistant to at least one drug. Resistance to isoniazid (11.1%), ethambutol (5.8%), or streptomycin (5.3%) was more common than resistance to rifampin (2.1%). The preva-lence of primary multidrug resistance was 2.1%. Among the 62 isolates from patients with histories of anti-TB treatment, the prevalence of resistance to any of the four drugs was 64.5%. The acquired resistance rates to individual drugs were 54.8% to isoniazid, 17.7% to streptomycin, 45.2% to rifampin, and 33.9% to ethambutol. Conclusions：The prevalence of drug resistance is very high in easterm Taiwan, and the surveys for anti-tuberculosis drug resistance should be repeated annually. Measures to decrease the multidrug-resistance rate are greatly needed.