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Primary Sinonasal Mucosal Melanoma with Unusual Long-Term Survival

原發性鼻竇及鼻黏膜黑色素瘤-罕見之長期存活病例報告

摘要


原發於鼻竇及鼻黏膜之黑色素瘤是一種罕見且極具侵犯性的疾病,其預後極差,存活率亦不高,病人很少能夠長期存活。本文報告一位70歲的男性病患,在接受原發部位之腫瘤切除之後,仍發生了多次的遠端轉移,包括腎上腺、腎臟、腰椎、脾臟等器官,每次均給予包括手術或放射線治療等救援性治療,至今存活已超過十年。由此一病例可以肯定積極的救援性治療對延長存活期之重要價值。

並列摘要


The primary sinonasal mucosal melanoma is a rare entity. It has a grave clinical course with a dismal prognosis. A patient with long- term survival is very unusual. We report a 70-year-old male with a primary sinus mucosal melanoma and multiple metachronous disseminations. The patient underwent curative surgery for the primary sinus lesion and multiple salvage therapies for distant failures. A survival period of more than 10 years was achieved. We establish the value of repeated salvage therapies in prolonging survival time for this patient with a primary sinonasal mucosal melanoma.

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