Development of a Multichannel Recording System for Bioelectrical Activities in Freely Moving Rats and Its Application to Sleep and Absence Epilepsy

自由活動大鼠之多通道生物電訊號記錄系統之建立以及在睡眠與失神癲癇研究之應用

蕭富仁(Fu-Zen Shaw)

《慈濟醫學雜誌》 18卷2期 (2006/04) Pp. 81-90

https://doi.org/10.6440/TZUCMJ.200604.0081

摘要

在行為神經科學研究方面，連續的多通道記錄各種生物電訊號（腦電圖、肌電圖與心電圖等）對於了解大腦活性與相關生理訊號變化有相當大的幫助。在這一篇回顧文章我将針對我個人研究興趣進行以下主題的回顧，(1)有關於在清醒自由活動大鼠之多通道記錄分析系統的最近發展與可能未來發展方向；(2)有關於睡眠對學習與記憶穩固以及其他感覺訊息處理方式的探討；(3)探討失神癫癇的大腦網路操作方式以及失神癲癇與睡眠之關係。希望能藉由了解睡眠與失神癲癇的生理功能與操作機轉進而幫助未來相關生理與病理的操弄。

關鍵字

慢波睡眠 ； 神經可塑性 ； 伽瑪波 ； 失神癲癇 ； 睡眠紡錘波

並列摘要

In the field of behavioral neuroscience, the continuous and mutichannel recording of bioelectric activities, such as electroencephalography, electromyography, and electrocardiography, is necessary to understand the physiological correlates with brain activity. In this review, I address issues based on my research interests: (1) the recent development and future directions of multichannel recording and analysis systems in freely moving rats are discussed; (2) functional aspects of sleep in sensory processing, including sleep-dependent learning and memory consolidation and the possibility of sleep learning, are included; and (3) the network operation of absence epilepsy is elucidated, particularly the relationship between sleep and absence epilepsy. It is hoped that improved understanding of sleep and absence epilepsy will ultimately lead to more-effective treatment options.

並列關鍵字

slow-wave sleep ； neural plasticity ； gamma oscillation ； absence epilepsy ； sleep spindle