- 期刊
Cardiovascular Actions of Endomorphin-2 in the Nucleus Tractus Solitarius
並列摘要
Cardiovascular effects of microinjections of endomorphin-2 into the medial subnucleus of the nucleus tractus solitarius (mNTS) were studied in adult, male, urethane-anesthetized, Wistar rats. Microinjections of endomorphin-2 into the mNTS elicited depressor and bradycardic responses via mu-opioid receptors. Similar microinjections of endomorphin-2 attenuated the carotid sinus and aortic baroreflex responses. Endomorphin-2 inhibits GABAergic mNTS neurons via mu-opioid receptors, causing disinhibition which results in excitation of secondary mNTS neurons. This effect causes depressor and bradycardic responses. Endomorphin-2 also inhibits glutamate release from baroreceptor terminals via mu-opioid receptors located on these terminals and attenuates baroreflex responses.
延伸閱讀
- Takahashi, K. (2012). Distribution of Urocortins and Corticotropin-Releasing Factor Receptors in the Cardiovascular System. International Journal of Endocrinology, 2012(), 364-373. https://doi.org/10.1155/2012/395284
- 林佩姿、張展維、戴慶玲（2013）。Case Report of Daunorubicin-Induced Acute Cardiac Toxicities。臺灣臨床藥學雜誌，21(3)，253-260。https://doi.org/10.6168/FJCP.2013.2103.07
- 徐仁皇（2007）。Characterization of TXAS-null aortic endothelial cells〔碩士論文，中原大學〕。華藝線上圖書館。https://doi.org/10.6840/cycu200700858
- Guyenet, P. G., Bayliss, D. A., Mulkey, D. K., Stornetta, R. L., Moreira, T. S., & Takakura, A. T. (2008). The Retrotrapezoid Nucleus and Central Chemoreception. 慈濟醫學雜誌, 20(4), 239-242. https://www.airitilibrary.com/Article/Detail?DocID=10163190-200812-20-4-239-242-a
- Li, M. (2009). The association of adiponectin with cardiovascular disease and endothelial progenitor cell [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200016398