- 期刊
Toxic Epidermal Necrolysis Due to Lamotrigine Monotherapy for Bipolar Disorder
並列摘要
Toxic epidermal necrolysis (TEN) is a life-threatening mucocutaneous reaction to drugs. Lamotrigine is an antiepileptic agent not chemically related to the aromatic anticonvulsants that is also prescribed for mood disorder. Although adverse reaction from lamotrigine have been reported after a low initial dosage, the risk of developing TEN during lamotrigine therapy is rare when recommended guidelines for the dosing schedule are carefully followed. We present a 35-year-old woman with a mood disorder who developed TEN after about 10 days of lamotrigine (50 mg daily) monotherapy. She developed generalized maculopapular eruptions that progressed until more than 90% of her body surface area was involved, with extensive epidermal detachment. The lesions affected her conjunctival, oral, nasopharyngeal, genital, and vaginal mucosa. Lamotrigine was immediately discontinued. After receiving systemic antihistamine and corticosteroid treatment, the patient had a complete recovery.
延伸閱讀
- 張惠茹、郭嘉琪、白佳玉、吳貞鋆（2017）。Urgent Nursing Experience of a Steven-Johnson syndrome Patient Complicated with Toxic Epidermal Necrolysis。領導護理，18(4)，34-47。https://doi.org/10.29494/LN.201712_18(4).0004
- Wu, T. S., Lee, C. C., Lin, J. T., Hsu, H. H., Lin, S. T., Jong, Y. J., & Shen, E. Y. (1993). Leigh Disease (Subacute Necrotizing Encephalomyelopathy): Report of One Case. Acta Paediatrica Sinica, 34(4), 301-307. https://www.airitilibrary.com/Article/Detail?DocID=00016578-199308-34-4-301-307-a
- 黃立言、劉秉一、鄭幼文、張俊梁、諶立中、許文欣、何裕鈞、柯朝元、柯富彰（2010）。Not Just a Dermatologic Disease: Toxic Epidermal Necrolysis from the Viewpoint of an Internist。內科學誌，21(1)，12-25。https://doi.org/10.6314/JIMT.2010.21(1).03
- Chou, C., Kuo, Y. R., Chang, C. H., Lee, S. S., Ou, S. F., Lin, T. R., & Huang, S. H. (2017). Retrospective Analysis of Toxic Epidermal Necrolysis Over a Period of 20 Years from a Single Institution. 臺灣整形外科醫學會雜誌, 26(2), 139-148. https://www.airitilibrary.com/Article/Detail?DocID=a0000593-201706-201707250030-201707250030-139-148
- 許庭綾、曾媖蘭、鄔恒斐、蔡秀鸞（2016）。Toxic Epidermal Necrolysis: A Case Report。台灣專科護理師學刊，2(1)，89-97。https://www.airitilibrary.com/Article/Detail?DocID=P20150413001-201602-201604250034-201604250034-89-97