Serum Uric Acid Changes in Patients Who Underwent Transurethral Resection of the Prostate (TURP)

經尿道攝護腺切除手術前後之病患血液中尿酸濃度之變化

陳子安(Tzu-An Chen) ； 劉善居(Shan-Ciu Liu) ； 胡非力(Philip Hu) ； 劉煥昀(Huan-Yun Liu) ； 傅延宗(Yian-Tzueng Fu)

《臺灣泌尿科醫學會雜誌》 17卷3期 (2006/09) Pp. 87-91

摘要

OBJECTIVE: An acute gout arthritis attack is occasionally found in elderly men with benign prostatic hyperplasia (BPH) who have received transurethral resection of the prostate (TURP). It may increase the length of stay in the hospital and increase medical costs. In this study, we evaluated the incidence of acute gouty arthritis and serum uric acid changes in patients who received TURP, and attempted to elucidate their relationships.
MATERIALS AND METHODS: From January 2002 to June 2003, fifty-two patients who receive TURP at the Armed Forces Taoyuan General Hospital were enrolled in this random study. Blood samplings were taken for serum uric acid level before and after TURP, respectively. In addition, serum sodium and the uric acid level in the urine were checked in 12 patients before and after the operation as well.
RESULTS: These patients had an average preoperative level of uric acid which rose from 5.929±1.776 mg/dL to an immediate postoperative average of 6.169±1.687 mg/dL (p＜0.05). There was a significant decrease in the serum uric acid concentration 24 hours postoperatively (5.706±1.514 mg/dL, p＜0.05) and a further decrease 48 hours postoperatively compared to the preoperative concentration (5.263±1.585 mg/dL, p＜0.05). The average serum sodium level dropped from 139.99±1.83 mmol/L preoperatively to 137.25±2.87mmol/L postoperatively (p＞0.05). Two patients experienced an acute gout attack after TURP, and their uric acid levels dropped slightly more than the uric acid level of those who did not experience a gout attack.
CONCLUSIONS: The serum uric acid level significantly dropped after TURP. Two of our 52 patients did suffer from acute gouty arthritis postoperatively. But there seemed to be no definite
relationships between the serum uric acid level changes and the acute gout attack after TURP. Further study of the uric acid level changes in blood and joint synovial fluid before and after the operation is recommended.

關鍵字

血清中尿酸濃度 ； 經尿道攝護腺切除手術

並列摘要

OBJECTIVE: An acute gout arthritis attack is occasionally found in elderly men with benign prostatic hyperplasia (BPH) who have received transurethral resection of the prostate (TURP). It may increase the length of stay in the hospital and increase medical costs. In this study, we evaluated the incidence of acute gouty arthritis and serum uric acid changes in patients who received TURP, and attempted to elucidate their relationships.
MATERIALS AND METHODS: From January 2002 to June 2003, fifty-two patients who receive TURP at the Armed Forces Taoyuan General Hospital were enrolled in this random study. Blood samplings were taken for serum uric acid level before and after TURP, respectively. In addition, serum sodium and the uric acid level in the urine were checked in 12 patients before and after the operation as well.
RESULTS: These patients had an average preoperative level of uric acid which rose from 5.929±1.776 mg/dL to an immediate postoperative average of 6.169±1.687 mg/dL (p＜0.05). There was a significant decrease in the serum uric acid concentration 24 hours postoperatively (5.706±1.514 mg/dL, p＜0.05) and a further decrease 48 hours postoperatively compared to the preoperative concentration (5.263±1.585 mg/dL, p＜0.05). The average serum sodium level dropped from 139.99±1.83 mmol/L preoperatively to 137.25±2.87mmol/L postoperatively (p＞0.05). Two patients experienced an acute gout attack after TURP, and their uric acid levels dropped slightly more than the uric acid level of those who did not experience a gout attack.
CONCLUSIONS: The serum uric acid level significantly dropped after TURP. Two of our 52 patients did suffer from acute gouty arthritis postoperatively. But there seemed to be no definite
relationships between the serum uric acid level changes and the acute gout attack after TURP. Further study of the uric acid level changes in blood and joint synovial fluid before and after the operation is recommended.

並列關鍵字

serum uric acid ； transurethral resection of prostate TURP