Strategy for Maxillofacial Bone Regeneration Using Tissue Engineering Concept

Minoru Ueda

《Journal of Genetics and Molecular Biology》 13卷2期 (2002/06) Pp. 133-133

https://doi.org/10.30047/JGMB.200206.0010

並列摘要

Our tissue engineering approaches for bone regeneration generally can be divided into three categories.
The first approach is delivering signaling molecules that can act on cells already present in adjacent tissue and causes them to migrate and differentiate tissue structure. The platelet rich plasma (PRP) fundamentally involves the universal initiators of almost all wound healing. PRP is also advantageous when used with synthetic bone substitutes, such as beta-tricalcium phosphate granulates.
The second approach is stem cell transplantation with macro porous matrix. Bone marrow cells are harvested iliac crest, and mesenchymal stem cells (MSC) are cultured and expanded. The porous ceramics with cultured cells showed active bone formation and almost same effects as the autogenous bone grafting.
The third approach for bone formation is mechanical stress in tissue engineering. Mechanical stress is widely known as important signal to activate the cell growth, and the tissue regeneration. To analyze the effect of mechanical stress to the osteoblastic cells, the cyclic stimulation is applied to the osteoblast cultured on the silicon rubber membrane. The osteoblastic phenotype is verified by alkaline phosphate and it showed 20% increasing of ALP than the control group.
In this presentation, the general strategy for maxillofacial bone regeneration using tissue engineering concept will be introduced.