Tissue Engineering of Pancreas

Feng-Huei Lin

《Journal of Genetics and Molecular Biology》 13卷2期 (2002/06) Pp. 145-145

https://doi.org/10.30047/JGMB.200206.0016

並列摘要

Like other human organs, donor pancreases are in very short supply. In USA, it is estimated that only approximately 1000 pancreases are recovered each year. Even with improved procurement of human organs, the supply of donor tissue would remain quite inadequate if pancreatic transplantation were to be developed as an effective therapy. In patients with insulin-dependent diabetes mellitus, there is a marked decrease in the number of insulin-producing islet cells of the pancreas. In the past, animal or human recombinant insulin have provided he replacement therapy required by these patient. Unfortunately, injected insulin cannot precisely mimic the ability of the normal pancreas to regulate blood glucose concentrations. There is hope that transplantation of islets of Langerhans will eliminate the need for daily insulin injections, and will prove effective in preventing or retarding the development of complications associated with diabetes. A umber of immunoisolation systems have been developed and refined during the past several years in which the transplanted tissue can be separated from the immune system of the host by a selectively permeable membrane. This approach has the potential not only to allow allogenic transplantation of cells and tissues without immunosupression, but also to permit the use of xenografts. In the study, we try to develop a bioceramic cage as immunoisolation system in the allograft transplantation for insulin-dependent diabetes mellitus treatment. The porous ceramic with good biocompatibility will be prepared by biphasic calcium phosphate and lining a thin film of extracellular matrix on the inner wall of the cage to provide a good environment for pancreas seeding.