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Network Modeling of Drosophila External Sensory Organ Precursor Formation: The Role of Recently Studied Genes

並列摘要


In order to find out how computational modeling in dynamical simulation of molecular biological network may help researches in genetics and molecular biology, we have performed computer simulation on cell fate determination in development. For sensory organ precursor (SOP) formation in Drosophila development, we have investigated a number of models involving lateral inhibition through cell-cell interaction. For genes that were recently identified to be associated with formation of SOP, senseless and phyllopod, we test the models’ robustness through the parameter space of the models. We conclude that the control of the lateral inhibition network is further enhanced by the new reactions.

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