內質網壓力與第二型糖尿病

Endoplasmic Reticulum Stress and Type 2 Diabetes Mellitus

謝旻晃(Min-Huang Hsieh) ； 莊立民(Lee-Ming Chuang)

《內科學誌》 17卷5期 (2006/10) Pp. 204-211

https://doi.org/10.6314/JIMT.2006.17(5).02

摘要

內質網是細胞內修飾、折疊分泌性蛋白質和膜蛋白的一個重要胞器，在細胞面對壓力時也扮演了一個關鍵的反應角色，來處理分解一些折疊不良的蛋白質。但是當過多的內質網壓力存在時，就會引發細胞死亡。目前認為第二型糖尿病形成的原因也和內質網壓力有關。同時，因為貝它細胞中胰島類澱粉多胜肽失去原有的三級結構而堆積聚合造成貝它細胞喪失或功能失調，所以它也被視為一種構形疾病。

關鍵字

內質網壓力 ； 未折疊蛋白質反應 ； 伴隨蛋白 ； 凋亡 ； 構形疾病 ； 胰島類澱粉多胜肽

並列摘要

Endoplasmic reticulum (ER) is an important intracellular organelle responsible for modifying and folding newly synthesized secretory and membrane proteins. Perturbations of ER homeostasis affect protein folding and cause ER stress. A key player in the cellular stress response is in the ER. The ER provides quality control system to refold and/or degrade misfolded proteins. The unfolded protein response, however, can trigger cell death if ER dysfunction is severe or prolonged. It is thought that the ER stress is associated with the pathogenesis of type 2 diabetes. Because the islet amyloid polypeptide in beta cells undergoes a change in tertiary structure followed by self-association and tissue deposition, which eventually causes beta cell dysfunction, type 2 diabetes is also defined as a conformational disease.

並列關鍵字

Endoplasmic reticulum stress, ER stress ； Unfolded protein response, UPR ； Chaperone ； Apoptosis ； Conformational disease ； Islet amyloid polypeptide, IAPP