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Very Low HbA1c Values in a Patient with Clinical Silent Hemoglobin Variant (Hemoglobin J)-A Case Report

臨床上無症狀的變異血色素(血色素J)患者產生極低的糖化血色素值-一個病例報告

摘要


糖化血色素是目前最能準確反映過去二至三個月血糖控制情況的數據。根據美國糖尿病學會的建議,所有糖尿病患者必須定期檢驗糖化血色素,並且控制在7%以下,以預防慢性併發症產生。我們報告一位71歲的第2型糖尿病患者,檢驗出極低之不相符的糖化血色素值,經血色素電泳分析確認變異血色素(血色素J)的存在。藉此病例糖化血色素之分析,強調各臨床實驗室了解其HbA1c檢驗方法的限制,還有靠目視檢查離子交換色彩層析譜來發現因變異血色素而產生不正常的重要性。

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並列摘要


Glycohemoglobin (GHb) most accurately reflects the previous two to three months of glycemic control. According to the American Diabetes Association, GHb should be measured regularly in all patients with diabetes, and values should be maintained below 7% to prevent the risk of chronic complications. Herein, we report a case of a 71-year-old type 2 diabetic female patient with extraordinary low HbA1c values. The hemoglobin electrophoresis identified the existence of Hemoglobin (Hb) variant-Hb J. Our case study emphasized that clinical laboratories should be aware of limitations of their HbA1c assay methods as well as the importance of visual inspection of ion exchange chromatograms to detect abnormalities caused by Hb variants.

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