γ-Benzene Hexachloride造成癲癇發作之不良反應－病例報告

γ-Benzene Hexachloride Induced Seizure-A Case Report

郭俊男(Chun-Nan Kuo) ； 林文亮(Wen-Liang Lin) ； 張家銘(Chia-Ming Chang) ； 柯文謙(Wen-Chien Ko) ； 李欣純(Hsin-Chun Lee) ； 李南瑤(Nan-Yao Lee) ； 黃欽威(Chin-Wei Huang) ； 高雅慧(Yea-Huei Kao Yang)

《內科學誌》 18卷3期 (2007/06) Pp. 152-157

https://doi.org/10.6314/JIMT.2007.18(3).08

摘要

疥瘡是由Sarcoptes scabiei而致，每年全世界大約會發生三億個疥瘡的案例。γ-Benzene hexachloride是一種可用來治療疥瘡的藥品，但使用後可能會產生一些不良反應，如皮膚炎、麻木、焦慮、震顫、抽筋、癲癇發作、再生不良性貧血及全部血球減少，其中癲癇在這些不良反應中是比較嚴重的。本文報導一位七十五歲女性在本次住院前經皮膚科醫師診斷有疥瘡，囑以γ-benzene hexachloride 1% cream使用，一星期後於接受血液透析時發生低血壓且有發燒情形而住院，住院期間仍使用了兩次，四天之後有癲癇發作的現象。我們藉由回顧文獻，討論促成此不良反應發生的因素及可能的機轉，並提出處方須注意的事項。

關鍵字

疥瘡 ； γ-Benzene hexachloride ； 不良反應 ； 癲癇發作

並列摘要

Scabies is an infectious disease caused by Sarcoptes scabiei. There are three hundred million cases around the world every year. γ-Benzene hexachloride (γ-BHC) is a scabicide used to treat the disease. Adverse effects associated with γ-BHC include dermatitis, numbness, anxiety, tremor, cramps, seizure, aplastic anemia and pancytopenia. Seizure is a serious one among these. We report a 75-year-old woman who suffered from scabies, which was diagnosed one week before this admission and γ-BHC cream was prescribed. Because of fever and hypotention during hemodialysis, she was admitted and γ-BHC was used twice during admission. Seizure occurred 4 days after the last use of γ-BHC. We reviewed the literatures and discussed the predisposeing factors and the possible mechanism of γ-BHC induced seizure. The correct method of using γ-BHC is reemphasized and clinicians should be cautious when prescribing it.

並列關鍵字

Scabies ； γ-BHC ； Adverse effect ； Seizure