The early presentation of pulmonary arterial hypertension is insidious, so it is easy to be missed in our practice. As the high pulmonary arterial pressure persists, it complicates cardiopulmonary resuscitation. We can measure the pulmonary vascular pressure by transthoracic echocardiography or by pulmonary arterial catheter monitoring. Some medications, such as vasopressors, inotropes, pulmonary vasodilators, and diuretics, are shown to slow the progression of cor pulmonale. We reviewed the literatures of pulmonary arterial hypertension management and provide a drug reference for clinicians.