高血壓腎病變已是末期腎病最重要的原因之一,而高血壓也是慢性腎衰竭最常見的併發症;長期高血壓會使腎臟的血管結構發生硬化,進而使腎功能惡化。會影響高血壓腎病變進程的因素包括高血壓本身的控制、蛋白尿的程度、腎臟功能、血脂肪、人種、基因等。以控制血壓的藥物來說,還是要依照病患的狀況來做調整,但若以單純的高血壓腎病變來說還是以血管張力素轉換抑制劑或第二型血管張力素受體拮抗劑爲主,可以減少腎臟衰竭的機會。然而在使用這些藥物時要很小心的追蹤其腎功能及鉀離子以減少併發症的發生。
Hypertensive kidney disease is one of the most common cause of end stage renal disease. Hypertension is also the most common complication of chronic kidney disease. Chronic hypertension makes the vessels of kidney become sclerotic and further deteriorate renal function. Factors that correlate with the progression of hypertensive kidney disease include blood pressure control, the severity of proteinuria, renal function, hyperlipidemia, races and genes, etc. The most effective medications for hypertensive kidney disease are angiotensin converting enzyme inhibitors and angiotensin Ⅱ receptor blockers. However, physicians should monitor renal function and serum potassium cautiously to decrease the risk of complications.