Co-presence of diabetes and tuberculosis, which are expected to be among the most common diseases in the 21st century, is not uncommon. The difficulties faced by people treated for both diseases simultaneously have a major influence on their life quality. This article explored the mechanisms of diabetes with tuberculosis, analyzed patient characteristics, clinical presentation, and treatment outcomes in tuberculosis patients with or without diabetes and suggested several principles for optimizing their care. The analytical results of this study provide a reference not only for clinical treatment and community care for this important patient group, but also for establishing infection control policies.