As renal function deteriorates to uremic stage, the whole body involved. Influence on hemostasis is just a part, called uremic bleeding, likely to be multifactorial, including accumulation of uremic toxins and anemia secondary to ineffective erythropoiesis, eventually result in platelet dysfunction. The traditional way for evaluating bleeding tendency in uremic patients is bleeding time, which is much invasive and has poor reproducibility. New methods are developed for investigation of platelet function, partially applied to evaluation of uremic bleeding. Present treatment of uremic bleeding includes dialysis, correction of anemia and desmopressin therapy. It is primarily based on improvement of laboratory data, but lacks direct impact on outcome. Further clinical trials are needed to prove.