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  • 期刊

氫離子幫浦抑制劑長期治療之不良反應及其臨床重要性

Clinical Importance of Adverse Effect in Long Term Use of Proton-Pump Inhibitors

摘要


氫離子幫浦抑制劑一直被認為是治療胃酸相關疾患,安全而有效的首選藥物。但隨著使用經驗的增加及病人治療期間的延長,這類藥物可能會造成的不良反應及長期生理病理變化也逐漸明瞭。本文就過去文獻中氫離子幫浦抑制劑長期使用所造成的不良反應及相關病理機轉,包含高胃泌素血症相關之病理變化、骨折之風險、感染之風險,及與clopidogrel交互作用之臨床證據,作一重點性的文獻回顧。

並列摘要


Proton pump inhibitors are recognized as safe and effective in acid related disorders, and are first choices in these diseases. However, with increased clinical experiences and extended treatment duration in recent years, potential adverse effects and pathophysiological change are reported. We reviewed recent advance in knowledge and mechanism of the adverse events related to proton pump inhibitor use, including hypergastrinemia, bone fracture, infection and drug interaction with Clopidogrel. We aim to provide updated information on clinical concerns and evidences in using proton pump inhibitors.

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