Terbinafine導致的藥物性肝損傷：一病例報告及文獻回顧

Terbinafine Induced Liver Injury: A Case Report and Review of Literatures

徐承毓(Cheng-Yu Hsu)

《內科學誌》 23卷2期 (2012/04) Pp. 130-136

https://doi.org/10.6314/JIMT.2012.23(2).07

摘要

Terbinafine是一個有效的抗黴菌劑，它被廣泛的使用著。但須切記，有3.3 %左右肝功能異常的發生率報告，儘管有症狀的肝膽功能異常罕見；但在特異體質的個體，有可能導致嚴重的肝炎發生。我們報告一個病例，服用terbinafine 250mg兩週，在開始用藥後的第四週，發生嚴重的肝細胞性肝損傷。我們對terbinafine造成的藥物性肝損傷的機轉，及藥物不良反應計分方法，做文獻上的探討。

關鍵字

藥物性肝毒性 ； 藥物性肝損傷 ； 肝細胞性肝損傷 ； 膽汁鬱積性肝損傷 ； 混合型肝損傷 ； 藥物不良反應

並列摘要

Terbinafine is widely applied and also is an effective antifungal agent. Although It was rarely found symptomatic hepato-biliary abnormality, but severe hepatitis probably occurred in idiosyncratic individuals. One case was reported, that he took terbinafine 250 mg daily for two weeks. The severe heptatocellular liver injury developed four weeks after the first dose of terbinafine. The mechanism of terbinafine induced liver injury and scales for adverse drug reaction were discussed by literature. (J Intern Med Taiwan 2012; 23: 130-136)

並列關鍵字

Drug hepatotoxicity ； Drug induced liver Injury ； Hepatocellular liver injury ； Cholestatic liver injury ； Mixed liver injury ； Adverse Drug Reaction, ADR