The impact of global climate change on human health is diverse and significant, including respiratory diseases, cardiovascular diseases, kidney diseases, gastrointestinal diseases, neurological diseases, mental health, infectious diseases, heat-related illness, accidents and even cancer. The greenhouse effect is processing and there are upward trends in global temperature. Extreme weather events also become more frequent and severe. Climate change and variability is higher in Taiwan due to complex topography. By understanding how climate change can result in associated threats to health, we can minimize or avoid adverse health impacts.