Following the rapid development of the endoscopic procedure, more and more patients received endoscopic examination, as well as interventional treatments. These years, the increasing cardiovascular events and the newly developed antiplatelet drugs make the endoscopists have to take the use of these drugs, and the associated risk of bleeding and thromboembolic event into consideration during the management. According to the current guidelines in western countries, it is unnecessary to stop aspirin before receiving most endoscopic procedures. However, not all of the endoscopists in Asia agree with it. In future, it is an important issue in evaluation of the benefit and risk of the use of antiplatelet drugs during endoscopic intervention.