Risk Factors for Mortality in Non-pregnant Adults with Group B Streptococcus Bacteremia

非懷孕成人B型鏈球菌感染的死亡因素分析

陳昶華(Chang-Hua Chen) ； 張家築(Chia-Chu Chang)

《內科學誌》 24卷2期 (2013/04) Pp. 131-136

https://doi.org/10.6314/JIMT.2013.24(2).07

摘要

This study analyzed the prognostic factors of Group B streptococcus (GBS) bacteremia in non-pregnant adult patients in Central Taiwan. An observational study was conducted between January 1, 2001 and December 31, 2009 at the study hospital. The overall incidence rate of GBS bacteremia was 24.3 cases per 100,000 admissions during the study period. Among the 63 patients, 26 patients were male with a mean age of 57.1 years. The most common source of infection was skin and soft tissue infection (27, 42.9%). The C-reactive protein (CRP) and sepsis sign were markedly different between the expired and survival groups (8.8 ±8.9 mg/dL vs. 18.7±6.8 mg/dL, p=0.013 and 32.6% v.s. 64.1%, p＜0.001), respectively. The diastolic blood pressure on the day of diagnosis had a statistically significant difference between the two groups (81.3±11.8 mmHg vs.63.1±16.5 mmHg, p=0.033). The overall case fatality rate was 36.9% (17 cases). Elevated CRP level, low diastolic blood pressure and sepsis sign were most significant difference at the initial presentation, and were poor prognostic factors for mortality.

並列摘要

This study analyzed the prognostic factors of Group B streptococcus (GBS) bacteremia in non-pregnant adult patients in Central Taiwan. An observational study was conducted between January 1, 2001 and December 31, 2009 at the study hospital. The overall incidence rate of GBS bacteremia was 24.3 cases per 100,000 admissions during the study period. Among the 63 patients, 26 patients were male with a mean age of 57.1 years. The most common source of infection was skin and soft tissue infection (27, 42.9%). The C-reactive protein (CRP) and sepsis sign were markedly different between the expired and survival groups (8.8 ±8.9 mg/dL vs. 18.7±6.8 mg/dL, p=0.013 and 32.6% v.s. 64.1%, p＜0.001), respectively. The diastolic blood pressure on the day of diagnosis had a statistically significant difference between the two groups (81.3±11.8 mmHg vs.63.1±16.5 mmHg, p=0.033). The overall case fatality rate was 36.9% (17 cases). Elevated CRP level, low diastolic blood pressure and sepsis sign were most significant difference at the initial presentation, and were poor prognostic factors for mortality.

並列關鍵字

Clinical presentations ； Group B Streptococcus ； Bacteremia ； Mortality ； Prognostic factor